منابع مشابه
Intracellular chloride activities in canine tracheal epithelium. Direct evidence for sodium-coupled intracellular chloride accumulation in a chloride-secreting epithelium.
Canine tracheal epithelium secretes Cl via an electrogenic transport process that appears to apply to a wide variety of secretory epithelia. To examine the mechanisms involved, intracellular chloride activity, acCl, was measured with Cl-selective intracellular microelectrodes. The results indicate that when the rate of secretion was minimal acCl was 37 mM; with stimulation of secretion the intr...
متن کاملIntracellular potassium and chloride channels: an update.
Channels selective for potassium or chloride ions are present in all intracellular membranes such as mitochondrial membranes, sarcoplasmic/endoplasmic reticulum, nuclear membrane and chromaffin granule membranes. They probably play an important role in events such as acidification of intracellular compartments and regulation of organelle volume. Additionally, intracellular ion channels are targ...
متن کاملRelationship between intracellular pH and chloride in Xenopus oocytes expressing the chloride channel ClC-0.
During maturation of oocytes, Cl(-) conductance (G(Cl)) oscillates and intracellular pH (pH(i)) increases. Elevating pH(i) permits the protein synthesis essential to maturation. To examine whether changes in G(Cl) and pH(i) are coupled, the Cl(-) channel ClC-0 was heterologously expressed. Overexpressing ClC-0 elevates pH(i), decreases intracellular Cl(-) concentration ([Cl(-)](i)), and reduces...
متن کاملPotassium-coupled chloride cotransport controls intracellular chloride in rat neocortical pyramidal neurons.
Chloride (Cl(-)) homeostasis is critical for many cell functions including cell signaling and volume regulation. The action of GABA at GABA(A) receptors is primarily determined by the concentration of intracellular Cl(-). Developmental regulation of intracellular Cl(-) results in a depolarizing response to GABA in immature neocortical neurons and a hyperpolarizing or shunting response in mature...
متن کاملGenetically Encoded Optical Sensors for Monitoring of Intracellular Chloride and Chloride-Selective Channel Activity
This review briefly discusses the main approaches for monitoring chloride (Cl(-)), the most abundant physiological anion. Noninvasive monitoring of intracellular Cl(-) ([Cl(-)]i) is a challenging task owing to two main difficulties: (i) the low transmembrane ratio for Cl(-), approximately 10:1; and (ii) the small driving force for Cl(-), as the Cl(-) reversal potential (E(Cl)) is usually close ...
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ژورنال
عنوان ژورنال: Current Opinion in Nephrology and Hypertension
سال: 2019
ISSN: 1062-4821
DOI: 10.1097/mnh.0000000000000502